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Host control of HIV-1

Prof Adrian Hill

Fredrik Vannberg, Sir Andrew McMichael, Pontiano Kaleebu, Assan Jaye.

HIV-1/AIDS in Africa is one of the most pressing public health problems of our generation. Despite a very large research spend much remains to be understood about the natural infection of HIV-1/AIDS in humans. This study seeks to bring together experts in human genetics and in the HIV field to analyse the host genetic component to HIV-1 disease progression and susceptibility to HIV-1 infection. Whole genome studies have been effective in linking specific genes to disease processes, thereby informing the scientific community about the importance of particular cellular pathways in disease development. This study will involve scientists from The Gambia, Uganda and South Africa, working together with the genetics and analysis teams at the Wellcome Trust Centre for Human Genetics at Oxford to link genomic variants to how quickly people infected with HIV-1 develop the immune suppressed state which defines AIDS.