Wellcome Trust Case Control Consortium

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Wellcome Trust Case Control Consortium (WTCCC1)

The Wellcome Trust Case Control Consortium (WTCCC) is a group of 50 research groups across the UK which was established in 2005. The WTCCC aims were to exploit progress in understanding of patterns of human genome sequence variation along with advances in high-throughput genotyping technologies, and to explore the utility, design and analyses of genome-wide association (GWA) studies. The WTCCC has substantially increased the number of genes known to play a role in the development of some of our most common diseases and has to date identified approximately 90 new variants across all of the diseases analysed. As well as confirming many of the known associations, some 28 in total, the WTCCC has also identified many novel variants that affect susceptibility to disease.

The WTCCC aims to complete the initial survey of common variation for association to disease, and to examine the replicated association signals detected through resequencing and fine-mapping. The WTCCC will also carry out a major experiment to address the genome-wide measurement of copy number variation (CNV) within the 19,000 (tbc) samples tested in phase one (16,000 disease samples and 3,000 common controls) and additional samples from breast cancer. Further information

Data release

Genotype data from WTCCC1 is available by application to the Consortium Data Access Committee (cdac@sanger.ac.uk). To support the studies within WTCCC and also the independent studies, the WTCCC will first genotype 6,000 common controls; 3,000 from the 1958 British Birth Cohort and 3,000 from the UK Blood Service Collection, and the data will be made available immediately through the existing controlled data access mechanism of the WTCCC.